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增强伤口愈合与罗迪奥拉花植物体凝:提取,配方,和体内评估

Anandarajagopal Kalusalingam¹, Abdullah Khan², Mahibub Mahamadsa Kanakal²

¹School of Pharmacy, KPJ Healthcare University, Nilai, Negeri Sembilan 71800, Malaysia.

Current pharmaceutical design

|March 21, 2025

概括

罗迪奥拉植物体凝显著增强伤口愈合,显示完整的组织再生. 这种新的配方改善了吸收和皮肤保留,以有效护理伤口.

科学领域:

药理学和制药科学药理学和制药科学
皮肤病学皮肤病学
草药研究草药研究

背景情况:

研究罗迪奥拉的治疗潜力,用于伤口愈合.
解决生物活性化合物的皮肤吸收和保留方面的挑战.

研究的目的:

制定和评估Rhodiola rosea植物体凝,以改善伤口愈合.
将乙醇提取物优化为植物体复合物,以提高生物可用性.

主要方法:

使用Box-Behnken设计的植物体复合物配方.
通过GC-MS,FTIR和SEM进行表征.
在Wistar大鼠的体外释放研究和体内伤口愈合评估.

主要成果:

优化的配方实现了高产量 (92.64%),小颗粒大小 (355 nm) 和高捕获效率 (93.98%).
与提取物和标准治疗相比,植物体凝在体内表现出优异的伤口愈合 (在第14天减少98.16%).
组织病理学证实了完整的组织再生和有组织的原纤维.

结论:

罗迪奥拉的植物体凝显示出作为有效的伤口愈合剂的巨大潜力.
建议进行进一步的研究,以进行稳定性和人体皮肤透性研究.

关键词:

盒子-Behnken设计的设计.罗迪奥拉罗莎 (Rhodiola rosea) 是一种红植物.提取提取提取提取在体内评估.植物体凝是一种植物体凝.伤口愈合伤口愈合

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