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Updated: May 21, 2025

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身体位置对动态显微扩散系数的影响在人脑心脏循环期间的变化

Naoki Ohno¹, Tosiaki Miyati¹, Masatomo Uehara²

¹Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Journal of magnetic resonance imaging : JMRI

|March 21, 2025

概括

大脑明显扩散系数 (ADC) 随心脏周期动态变化. 这项研究发现,动态ADC (ΔADC) 和平均ADC (ADCmean) 在坐姿相比躺姿显著更高.

科学领域:

神经成像是一种神经成像.
生理学生理学生理学
医学物理医学物理

背景情况:

心脏周期期间表面扩散系数 (ΔADC) 的动态变化反映了大脑水的波动和内条件.
身体位置显著影响内状况,但由于常规MRI限制,其对ΔADC的影响还未得到充分研究.

研究的目的:

研究身体位置对大脑 ΔADC 和平均ADC (ADCmean) 的影响.
通过使用多姿势MRI系统,比较卧卧和坐姿之间的这些参数.

主要方法:

这是一项前性研究,涉及9名健康的男性志愿者 (平均年龄为23.5岁).
使用0.4 T多姿势MRI系统与心电学同步扩散回声平面成像序列.
获得的扩散加权图像在b值为0和500s/mm2时,无论是躺着还是坐着.

主要成果:

与卧卧姿相比,坐姿时的 ΔADC 和 ADC 均值都显著升高.
具体来说,ΔADC从0.68增加到0.84 × 10−3 mm2/s,ADC的平均值从0.79增加到0.87 × 10−3 mm2/s.
心率在坐姿 (73.8次/分钟) 和卧姿 (58.1次/分钟) 中也显著更高.

结论:

大脑的 ΔADC 和 ADC 平均值在坐姿相比躺姿时显著更高.
这些发现突出了姿势对脑的生理参数的影响,可以通过MRI测量.

关键词:

看似的扩散系数.扩散加权成像技术的使用.多姿势核磁共振成像 (MRI) 的方法

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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...