基于硫化银量子点的双开关度探针,用于复杂矩阵中同时测量肌和
Hagar A Moustafa1, Ahmed S Abo Dena1,2, Ibrahim M El-Sherbiny1
1Nanomedicine Laboratories, Centre for Materials Science, Zewail City of Science and Technology 6th of October City Giza Egypt ielsherbiny@zewailcity.edu.eg.
RSC advances
|March 21, 2025
概括
这项研究引入了一种新的光探针,用于快速同时检测肌素和离子. 这一进步有助于早期诊断病和相关疾病.
科学领域:
- 分析化学 分析化学
- 生物标志物检测检测 生物标志物检测
- 纳米技术纳米技术
背景情况:
- 肌素 (CRE) 和离子 (Ca2+) 是诊断慢性病 (CKD) 等疾病的关键生物标志物.
- 传统的CRE和Ca2+监测方法具有侵入性和耗时性.
- 低血症是一种低水平的疾病,会影响多个器官.
研究的目的:
- 开发一种快速,高度敏感和选择性的光探针.
- 为了使不同样本中的CRE和Ca2+能够同时确定.
- 克服传统诊断技术的局限性.
主要方法:
- 使用的Ag2S量子点 (QD) 经过聚乙烯胺和二糖酸伊米达修改.
- 在与CRE和Ca2+相互作用时,研究了QDs的光火.
- 使用HR-TEM,FTIR,DLS和泽塔电位测量进行探测器的特征.
主要成果:
- 已达到0.48μg mL-1的CRE和0.45μg mL-1的Ca2+检测极限.
- 已建立的线性范围为CRE的0.7-9.0μg mL-1和Ca2+的0.5-4.0μg mL-1.
- 报告的高回收值 (93.8-103.6%) 对于两个分析物.
结论:
- 开发的光探测器提供了一种敏感和选择性的方法,用于同时检测CRE和Ca2+.
- 这个系统有可能用于早期诊断脏疾病.
- 探测器的性能在各种实验条件下得到验证.
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