三甘油糖相关参数与结石的关联:来自NHANES 2007-2020年的横截面研究

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Hao Yu^1,2, Jian Wu^1,2

¹Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Translational andrology and urology

|March 21, 2025

概括

高甘油三糖 (TyG) 指数和肥胖指标与美国成年人结石风险增加有关. 控制胰岛素抵抗 (IR) 和肥胖可能有助于预防结石的形成.

科学领域:

代谢综合征是代谢综合征的一种.
腎臟病學 (nephrology) 是一種醫學專業.
公共卫生公共卫生

背景情况:

胰岛素耐药性 (IR) 可靠地使用甘油三糖 (TyG) 指数和肥胖指标 (如BMI,WC和WHtR) 进行评估.
与TyG相关的参数和结石患病率之间的关系仍未得到充分研究.

研究的目的:

调查与TyG相关的参数 (TyG指数,TyG-BMI,TyG-WC,TyG-WHtR) 与美国成年人结石患病率之间的关联.
探索这些参数对结石的非线性关系和诊断准确性.

主要方法:

从2007-2020年国家健康和营养检查调查 (NHANES) 中对15590名参与者的横截面分析.
使用了加权后勤回归,限制立方线 (RCS) 分析和接收器操作特征 (ROC) 分析.
进行了子组分析,以检查与高血压的相互作用.

主要成果:

与TyG相关的参数中最高四分之一的参与者显示结石的风险明显更高 (例如,TyG-WC OR:2.08,95% CI:1.66-2.60).
在TyG相关参数和结石患病率之间观察到非线性关联 (P为非线性<0.05).
TyG-WC显示了最高的诊断准确性 (AUC:0.6130);在非高血压患者中发现了更强的关联.

结论:

与TyG相关的参数与美国成年人结石患病率正相关.
控制胰岛素抵抗和肥胖可能对降低结石形成的风险至关重要.
这些发现凸显了TyG相关参数作为结石风险评估指标的潜力.

关键词:

三糖糖体质量指数 (TyG-BMI) 是指三糖糖体质量指数.胰岛素耐药性 (IR) 是一种结石结石是指结石的发生.三甘油糖 - 腰围 (TyG-WC) 的使用方法三甘油糖-腰与身高的比率 (TyG-WHtR)

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