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马萨·梅迪卡塔·费尔曼塔 (Massa Medicata Fermentata) 通过介导肠道微生物群和血清来治疗缺陷便秘

Kangxiao Guo^1,2, Yuan Tang², Tao Yang¹

¹National Engineering Laboratory for Rice and By-Product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, China.

Frontiers in cellular and infection microbiology

|March 21, 2025

概括

在小鼠中,Massa Medicata Fermentata治疗通过改变肠道微生物群和脑肠来改善缺陷便秘. 这种传统药物重新平衡了肠道菌群和调节物质P (SP),血管活性肠道 (VIP) 和素基因相关 (CGRP) 的水平.

科学领域:

胃肠病学胃肠病学
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

缺陷便秘与改变的脑肠和肠道微生物群有关.
了解这些相关性对于开发有效的治疗方法至关重要.

研究的目的:

为了研究缺陷便秘治疗和脑肠之间的相关性.
在便秘模型中评估Massa Medicata Fermentata对肠道微生物群和水平的影响.

主要方法:

建立了一个小鼠模型的脏缺乏性便秘.
干预组中使用了Massa Medicata Fermentata.
16S rRNA测序分析了肠道微生物群的组成.
ELISA测量了P物质 (SP),血管活性肠道 (VIP) 和素基因相关 (CGRP) 的血清水平.

主要成果:

马萨·梅迪卡塔 (Massa Medicata Fermentata) 治疗增加了便中的水含量,并缓解了便秘症状.
便秘导致SP降低,VIP和CGRP增加;Massa Medicata Fermentata调节了这些水平.
肠道微生物群的多样性在治疗后增加,主要和特征性的细菌发生了变化,包括*Candidatus*Arthromitus和*Ligilactobacillus*.
确定了与SP,VIP和CGRP的特定细菌相关性.

结论:

马萨·梅迪卡塔 (Massa Medicata Fermentata) 有效地缓解了小鼠的脏缺陷便秘.
治疗影响肠道微生物群和血清分泌.
它可能会影响短链脂肪酸的产生,从而影响脑肠.

关键词:

这是CGRP的CGRP.马萨·梅迪卡塔 (Massa Medicata) 是一个发酵的植物.SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP 一个VIP的VIP的VIP的我们的肠道微生物群.欠缺便秘脏便秘

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