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来自中国广西的牛中新型hunnivirus复合菌株的鉴定和家族遗传特征

Guangxin Zhang^1,2,3,4, Yuhang Luo^1,2,3,4, Jiajie Li^1,2,3,4

¹Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, China.

Frontiers in cellular and infection microbiology

|March 21, 2025

概括

洪尼病毒 (HuV) 在中国牛群中普遍存在,特别是腹的牛群,并且显示出显著的遗传多样性. 这项研究确定了一种新型重组菌株,表明了潜在的动物感染风险和需要持续监测的需要.

科学领域:

兽医病毒学兽医病毒学
分子流行病学分子流行病学
动物传染病研究研究

背景情况:

洪尼病毒 (HuV) 是Picornaviridae家族的成员,与动物的胃肠道问题和潜在的动物传播有关.
关于牛群中HuV流行率和遗传多样性的数据有限.

研究的目的:

在中国广西省牛群中调查HuV的流行率和遗传特征.
识别潜在的重组菌株并评估遗传多样性.
评估HuV与胃肠道症状的关联及其动物感染潜力.

主要方法:

采集和RT-PCR分析了1017个牛便样本 (2021-2023年).
对遗传多样性和重组的遗传学和序列分析.
五个选定的HuV阳性样本的全基因组测序.

主要成果:

总体HuV患病率为3.05%,在腹 (9.59%) 显著高于健康 (2.54%) 牛.
区域患病率各不相同,在柳州 (5.66%) 发现率最高.
鉴定了一种新的复合HuV菌株,并根据VP1和P1区域同质性证明了一种新的基因型;5'UTR分析显示II型IRES与人类帕雷科病毒相似.

结论:

在中国牛群中,HuV表现出显著的遗传多样性和区域适应性.
该病毒与牛的胃肠道症状有关,特别是在农业条件不佳的地区.
这些发现强调了HuV动物性传染的可能性以及持续监测的必要性.

关键词:

这里是牛群.腹腹腹腹腹腹胡尼病毒 (hunnivirus) 是一种病毒.植物遗传学特征的描述.再组合剂的使用情况.

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