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相关概念视频

Coronary Circulation01:21

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The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
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冠状动脉微血管功能障碍和右心室结构和功能.

Amélie Paquin1,2, Michael D Nelson1,3, Janet Wei1

  • 1Barbra Streisand Women's Heart Center, Department of Cardiology, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA.

Cardiovascular diagnosis and therapy
|March 21, 2025
PubMed
概括
此摘要是机器生成的。

冠状动脉微血管功能障碍 (CMD) 在怀疑缺血并没有阻塞性冠状动脉疾病的患者中没有显示与右心室 (RV) 结构或功能的联系. 需要进一步的研究来探索长期影响.

关键词:
右心室的右心室.心脏磁共振是一种心脏磁共振.冠状动脉微血管功能障碍 (CMD)冠状动脉挑性检测是指冠状动脉挑性检测.缺血和没有阻塞性冠状动脉 (INOCA).

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科学领域:

  • 心脏病学 心脏病学
  • 心血管成像 - 心血管成像
  • 血管生理学 血管生理学

背景情况:

  • 冠状动脉微血管功能障碍 (CMD) 与左心室 (LV) 变化有关,但其对右心室 (RV) 的影响不明.
  • 潜在的RV参与CMD可能源于缺血,共享的病理生理学,或增加后负载由于LV功能障碍或肺高血压.
  • 在CMD的背景下研究RV结构和功能对于全面了解心血管健康至关重要.

研究的目的:

  • 评估右心室 (RV) 结构和功能与侵袭性测量冠状动脉微血管功能障碍 (CMD) 之间的关系.
  • 评估心脏磁共振成像 (CMRI) 衍生RV参数和冠状动脉微血管功能之间的相关性,在怀疑缺血并没有阻塞性冠状动脉疾病 (INOCA) 的患者中.

主要方法:

  • 利用了WISE-HFpEF,WISE-preHFpEF和WISE-CVD队列中的297名参与者的数据.
  • 进行心脏磁共振成像 (CMRI) 进行RV结构和功能评估.
  • 进行了侵入性冠状动脉功能测试,以测量冠状动脉流量储备 (CFR) 和冠状动脉血流变化 (∆CBF) 作为对腺和乙胆的反应.

主要成果:

  • 没有发现RV参数 (例如,RV终端透析体积,RV喷射率,RV纵向应变) 与冠状动脉微血管功能的测量 (CFR,∆CBF) 之间有显著的相关性.
  • 这项研究是首次报告在怀疑INOCA的患者中侵入性测量CMD和CMRI评估的RV参数之间的关联.
  • 尽管样本规模很大,但研究结果表明,在这个人群中,RV异常和CMD之间没有并发关系.

结论:

  • 在怀疑INOCA的个体中,右心室结构和功能似乎没有同时受到冠状动脉微血管功能障碍的影响,也没有受到冠状动脉微血管功能障碍的影响.
  • 需要进行进一步的纵向研究,以确定VR恶化是否在CMD过程中晚些时候发展或在心力衰竭患者中与保留射出分数 (HFpEF) 发生.
  • 这些发现凸显了进一步研究CMD对RV健康的长期后果的需要.