患有HBV感染的患者的生活质量:系统性审查和元分析
Michael X Fu1,2, Gabriel Lambert1, Amelia Cook1,3
1Department of Metabolism, Digestion and Reproduction, Division of Digestive Diseases, Imperial College London, London, UK.
JHEP reports : innovation in hepatology
|March 21, 2025
概括
慢性乙型肝炎病毒 (HBV) 感染显著影响与健康相关的生活质量 (HRQOL),随着疾病的进展而下降. 调查结果为全球肝炎消除战略和经济分析提供了信息.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
背景情况:
- 慢性乙型肝炎病毒 (HBV) 感染影响全球近2.5亿人.
- 在HBV感染中,与健康相关的生活质量 (HRQOL) 并未得到很好的描述.
- 了解HRQOL对于以患者为中心的护理和公共卫生政策至关重要.
研究的目的:
- 总结有关HBV相关HRQOL的现有数据.
- 为了量化HBV疾病不同阶段的总结实用值.
- 探索影响HBV患者HRQOL的因素.
主要方法:
- 在 Embase,全球健康,PubMed 和 Web of Science 的系统文献搜索.
- 根据疾病阶段和仪器汇总的实用性得分的元分析.
- 调整为医疗保健支出 (CHE/GDP) 的元回归作为感知医疗保健重要性的代理.
主要成果:
- 包括来自19项研究的22篇文章 (10,311名患者),其中74%来自西太平洋地区.
- HRQOL随着HBV疾病进展的阶段而下降.
- 预测的平均效用得分:非肝硬化 (0.842),补偿性肝硬化 (0.820),不补偿性肝硬化 (0.722),肝细胞癌 (0.749).
结论:
- 慢性HBV感染会影响HRQOL,特别是在晚期.
- 这些发现支持全球消除肝炎的努力和经济分析.
- 需要在低收入环境和治疗效果方面进行进一步的研究.
相关概念视频
Diseases of the Liver and Gallbladder
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...


