儿童克罗恩病的文献分析,2014-2024年
Yanjing Zhu1,2, Yunhong Ma3, Zhengjiu Cui4
1The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in pediatrics
|March 21, 2025
概括
儿科克罗恩病的研究正在增加,美国是主要的出版物. 本文献分析可视化了儿科克罗恩病文献中的趋势和关键贡献者,以帮助未来的诊断和治疗.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠疾病 炎症性肠病
- 图书统计分析 图书统计分析
背景情况:
- 克罗恩氏病的发病率在儿童中不断上升,影响他们的健康和家庭.
- 有广泛的研究,但缺乏使用可视化方法的文献计量分析.
- 这项研究解决了对儿科克罗恩病文献的统计概述的需求.
研究的目的:
- 统计分析关于儿科克罗恩病的出版文献.
- 确定该领域的关键作者,国家,机构和期刊.
- 提供视觉总结,以支持未来的诊断和治疗.
主要方法:
- 来自Web of Science核心集合的选文献.
- 使用Citespace (6.2.R4) 和VOSviewer (1.6.18) 进行可视化和分析.
- 分析了作者,国家,机构,期刊,参考文献和关键词.
主要成果:
- 包括 3,177 个出版物,显示出日益增长的趋势.
- 丹·特纳发表的文章最多 (78篇);A.莱文是被引用最多的作者.
- 美国和特拉维夫大学在出版物方面领先; 儿科胃肠病学和营养学杂志出版最多.
- 关键文件包括ESPGHAN修订的港口标准和ECCO-ESPGHAN指南更新.
- "炎症性肠病"是最常见的关键词.
结论:
- 提供了儿科克罗恩病研究的视觉总结.
- 突出了该领域的主要贡献者和趋势.
- 旨在促进国际合作,促进儿童克罗恩病的研究.
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
144
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
144
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
106
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
106
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
123
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
123
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
288
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
288
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
92
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
92
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
103
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
103