尿中的DcR2/Cr水平预测了糖尿病病患者的结果
Jia Chen1,2, Weidong Wang1,2, Fang Yu1,2
1Department of Nephrology, Daping Hospital, Army Medical University, Chongqing, China.
Journal of clinical & translational endocrinology
|March 21, 2025
概括
尿诱受体2 (uDcR2) 预测糖尿病病 (DKD) 中的病进展. 较高的UDcR2水平表明脏不良结果的风险更高,这表明它有可能作为DKD管理的生物标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 生物标志物发现发现
背景情况:
- 糖尿病病 (DKD) 是末期病的主要原因.
- 尿诱受体2 (uDcR2) 与DKD中的管间纤维化有关.
- 在DKD中DcR2对结局的预测价值尚未得到充分确立.
研究的目的:
- 调查尿诱受体2 (uDcR2) 与活检证明糖尿病病 (DKD) 患者的结局之间的关联.
- 评估UDcR2作为DKD进展的预测生物标志物的潜力.
主要方法:
- 对153名活检证明的DKD患者的分析,按脏结局分类 (血清肌素增加或透析开始的复合结果).
- 使用ELISA测量DucR2水平并与临床参数 (ACR,SCr,eGFR,IFTA) 相对应.
- 评估脏DcR2mRNA和蛋白质表达,以及其与α-SMA的同位化.
主要成果:
- 在患有不良结局的患者中,观察到尿诱因受体2与肌素 (uDcR2/Cr) 的比率较高.
- uDcR2/Cr水平与ACR,SCr和IFTA正相关,与eGFR负相关.
- uDcR2/Cr表现出良好的预测性能 (AUC 0.825) 和更好的预测模型,当添加到现有标记,识别患者显著较低的存期.
结论:
- 尿诱受体2 (uDcR2) 是糖尿病病 (DKD) 中结局的独立预测因子.
- 升高的UDcR2水平与间歇性纤维化和管管缩的增加有关.
- uDcR2显示了提高DKD的预防和治疗策略的潜力.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
45
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
45
01:11Renal Failure: Dose Adjustments
51
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
51
01:23Renal Clearance
585
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
585
01:27Dialysis
244
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
244
01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
64
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
64
01:20Renal Corpuscle
1.4K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.4K