功能性便秘的儿童用透性药的断奶策略:一项多中心随机对照试验
Yoo Min Lee1, Ju Young Kim2, Kyung Jae Lee3,4
1Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.
停止治疗儿科功能性便秘 (FC) 的药,与减少剂量与频率相比,显示出类似的成功率. 较高的断奶前乳糖剂量可能会改善早期的结果,但整体成功率仍然很低.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床药理学 临床药理学
- 治疗疗效研究研究 治疗疗效研究
背景情况:
- 长期保持药对于管理儿童功能性便秘 (FC) 是必不可少的.
- 确定停止放松剂治疗的最佳策略对于持续治疗的成功至关重要.
- 这项研究研究了不同药物降低方法,用于停用乳糖在儿科FC.
研究的目的:
- 为了比较使用剂量降低与频率降低方法在患有FC的儿童中停止乳糖治疗的成功率.
- 确定切断乳糖治疗儿童的最佳策略.
- 分析断奶前乳糖剂量对断奶成功的影响.
主要方法:
- 一个开放的随机对照试验,涉及患有FC的儿童,成功地用乳糖治疗了三个多月.
- 患者被随机分为两组:逐渐减少剂量或在三个月内逐渐减少频率.
- 断奶成功被评估在12周,根据断奶前的乳糖剂量 (≤1.5g/kg/day与>1.5g/kg/day) 进行亚组分析.
主要成果:
- 剂量减少 (66.7%) 和频率减少 (57.1%) 组在12周的断奶成功率没有显著差异.
- 在这两组中,断奶成功率随着时间的推移而下降,没有显著差异.
- 高剂量组 (>1.5 g/kg/day) 在12周后的断奶成功率 (81.8%) 与低剂量组 (20%,P=0.04) 相比显著更高.
结论:
- 乳糖剂量或频率降低方法对儿科FC的整体断奶成功没有显著的影响.
- 断奶前的乳糖剂量超过1.5g/kg/天可能与更好的短期结果有关.
- 总体来说,断奶成功率很低,这表明需要谨慎的断药方案和持续的患者随访.
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