海莫菲勒斯流感型f型脑膜炎与心室内
Miri Nakashio1, Ryoko Nikaido1, Junichiro Nishi2
1Department of Pediatrics, Kakogawa Central City Hospital, Kakogawa, JPN.
Cureus
|March 21, 2025
概括
由于非b型Haemophilus influenzae引起的侵入性感染,如f型 (Hif),正在上升. 一个婴儿患有的Hif脑膜炎病例强调了对这些罕见但严重的感染需要进行监测.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 海莫菲勒斯流感 (Hi) 是儿童细菌性脑膜炎的主要原因.
- 海莫菲勒斯流感b型 (Hib) 疫苗已经减少了入侵性HI疾病 (IHD).
- 非b型菌株,如Haemophilus influenzae类型f (Hif),越来越多地与罕见的侵入性感染有关.
研究的目的:
- 报告一个罕见的Hif脑膜炎病例与婴儿的腹腔内.
- 突出非b型Hif菌株带来的挑战,特别是那些抗生素耐药的菌株.
- 强调监测Hif血清型和耐药性模式的重要性.
主要方法:
- 一个11个月大的男孩出现发烧和昏迷的病例报告.
- 诊断工作包括脑脊液 (CSF) 分析和脑MRI.
- 微生物学培养物发现Hif具有β-乳酸酶负安培素耐药性 (BLNAR).
主要成果:
- 该患者患有Hif脑膜炎,并由心室内瘤复杂化.
- 脑脊髓液分析显示了多细胞体和低血糖.
- 通过静脉注射抗生素和德甲的成功治疗导致完全解脱和完全康复.
结论:
- 侵袭性HIF感染,特别是BLNAR菌株,构成了新兴的威胁.
- 有效的管理需要仔细考虑抗生素耐药性模式.
- 对Hi血清型和抗菌素耐药性的持续监测对于改善患者的治疗结果至关重要.
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