在怀孕期间两点之间研究微生物组与精神困扰的关系:来自美国和瑞典队列的数据
Mary Kimmel1,2,3, Bangzhuo Tong4, Alfons Edbom Devall4,5
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Biological psychiatry global open science
|March 21, 2025
概括
肠道微生物组功能,特别是皮质醇降解,可能表明怀孕期间的精神痛苦. 美国女性较低的微生物皮质醇降解与更高的抑郁率和产后压力反应有关.
科学领域:
- 微生物组研究的研究.
- 肠-大脑轴 肠-大脑轴
- 怀孕期间的心理健康 怀孕期间的心理健康
背景情况:
- 在怀孕期间研究肠道微生物组及其功能能力.
- 检查肠道微生物组与孕妇心理困扰之间的关系.
- 在两个季度中比较两个不同的群体 (瑞典和美国).
研究的目的:
- 描述肠道微生物组及其与怀孕期间精神痛苦有关的功能.
- 探索潜在的肠道微生物组生物标志物用于肠-大脑轴健康.
主要方法:
- 在瑞典 (n=832) 和美国 (n=161) 队列的第二和第三季度便样本上的全基因组基因组学.
- 使用爱丁堡产后抑郁症量表来评估精神困扰.
- 通过主要坐标和基于距离的冗余分析分析功能性肠-大脑模块的分析.
- 在美国队列中,Trier社会压力测试后产后皮质醇测量.
主要成果:
- 确定了四个肠-大脑模块集群,与短链脂肪酸合成和皮质醇降解等功能有关.
- 在任何一个队列中,精神困扰亚型都没有显著地解释肠-大脑模块变化 (p > 0.05).
- 在美国队列中,下肠道微生物皮质醇降解与更高的抑郁症几率 (p=0.024) 和压力后产后皮质醇水平升高有关.
结论:
- 肠道微生物组的组成和功能,特别是皮质醇降解,可能与怀孕期间的精神痛苦有关.
- 肠道微生物组显示出作为肠-大脑轴健康的生物标志物的潜力.
- 需要进一步的研究来验证这些发现在不同的人群中.
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