设计和建造人工代谢途径,用于生物生产有用的化合物
1RIKEN Center for Sustainable Resource Science, Cell Factory Research Team, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Plant biotechnology (Tokyo, Japan)
|March 21, 2025
概括
合成生物学使用计算方法来设计代谢途径,以有效地生产化合物. 本综述涵盖了重要的技术和植物细胞在代谢工程中的潜力.
科学领域:
- 代谢工程是代谢工程.
- 合成生物学 合成生物学
- 生物技术是生物技术.
背景情况:
- 有效生产有用的化合物需要细胞代谢的最佳设计,包括碳流,能量平衡和氧化还原状态.
- 计算方法对于代谢工程中的合理设计和流量优化至关重要.
研究的目的:
- 审查合成生物学中基本的代谢设计技术.
- 讨论在合成生物学中使用植物细胞和基因用于化合物生产的潜力.
主要方法:
- 对代谢路径设计的计算科学方法的审查.
- 在合成生物学中对代设计-构建-测试-学习周期的分析.
- 探索用于代谢工程的植物性系统.
主要成果:
- 计算工具可以合理设计和优化代谢流.
- 涉及构建,测试和重新设计的代方法是有效代谢工程的关键.
- 植物细胞和基因提供了通过合成生物学产生有价值化合物的巨大潜力.
结论:
- 通过计算优化代谢途径对于高效的化合物生产至关重要.
- 合成生物学,特别是以植物为基础的系统,对生物技术应用具有前景.
相关概念视频
Synthetic Biology
4.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
4.7K
What is Metabolism?
112.8K
Overview
112.8K
Fates of Pyruvate
8.3K
Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
8.3K
Overview of Metabolism
29.4K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
29.4K
Bioremediation
18.1K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
18.1K


