脑功能连接的变化与健康对照中的皮肤过渡的耳朵迷走神经刺激相关
Daniel A Monti1, Nancy Wintering1, Faezeh Vedaei2
1Marcus Institute of Integrative Health, Department of Integrative Medicine and Nutritional Sciences, Thomas Jefferson University, Philadelphia, PA, United States.
Frontiers in human neuroscience
|March 21, 2025
概括
通过皮肤进行的耳膜迷走神经刺激 (TaVNS) 显著改变了大脑的功能连接,特别是在与情绪处理和认知相关的区域. 这些变化根据刺激频率和横向性而异,为TaVNS效应提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 心理生理学 心理生理学
背景情况:
- 神经刺激 (VNS) 显示出应激和焦虑管理的潜力.
- 有限的研究存在于通过皮肤耳膜VNS (TaVNS) 期间的功能性大脑变化,特别是关于频率和横向性的研究.
- 了解TaVNS对大脑连接的影响对于治疗应用至关重要.
研究的目的:
- 研究TaVNS如何影响健康个体的功能性大脑连接.
- 根据刺激频率和耳朵侧向 (左侧,右侧或两者) 探索连接变化的差异.
- 测试TaVNS改变情绪处理和调节领域的连接性的假设.
主要方法:
- 在TaVNS期间,50名健康参与者接受了功能磁共振成像 (fMRI).
- 使用MRI兼容的耳罩将TaVNS应用于左耳,右耳或两耳.
- 血液中依赖氧气水平 (BOLD) 的fMRI数据是在交替的5分钟"开启"和"关闭"刺激期间收集的.
主要成果:
- TaVNS诱导了功能性大脑连接的显著变化.
- 观察到前面对面的区域,边缘区域,胰岛和小脑的连接模式发生了变化.
- 认知网络,包括叶,突出网络和默认模式网络,也显示出显著的变化.
结论:
- 在健康的成年人中,TaVNS显然改变了功能性大脑连接.
- 研究结果强调了TaVNS对情绪调节和认知处理领域的影响.
- 这项研究为在临床人群中对TaVNS的未来研究提供了基础.
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