黄素和EGCG组合配方在纳米结构脂质载体中用于抗衰老应用
Chidchanok Prathumwon1, Songyot Anuchapreeda2, Kanokwan Kiattisin1
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
International journal of pharmaceutics: X
|March 21, 2025
概括
在纳米结构脂质载体 (NLC) 中封装的黄素和表甲基酸盐显示出增强的抗氧化和抗衰老皮肤益处. 这种在乳化剂中的组合为局部抗衰老应用提供了卓越的皮肤透和持续的传递.
科学领域:
- 药理学和皮肤病学
- 纳米技术在药物输送中的应用
- 自然产品化学 自然产品化学
背景情况:
- 来自黄的黄素 (Cur) 和绿茶中的表甲基酸盐 (EGCG) 具有已知的抗衰老特性.
- 结合Cur和EGCG可以为皮肤健康提供协同效益.
- 在Cur和EGCG的局部输送方面面临的挑战包括稳定性和生物可用性差.
研究的目的:
- 开发和评估一种新型局部配方的黄素和EGCG封装在纳米结构脂质载体 (NLCs).
- 通过协同组合和先进的传递系统来增强黄素和EGCG的抗氧化和抗衰老活性.
- 评估NLC-乳化剂配方中的活性化合物的皮肤透,保留和持续释放.
主要方法:
- 黄素和EGCG在最佳比例中结合在一起,并被纳米结构脂质载体 (NLC) 封装.
- 使用DPPH基清除,FRAP和脂质过氧化抑制试验来评估抗氧化活性.
- 通过测量SIRT1蛋白刺激和抑制原酶和弹性酶来评估抗衰老潜力.
- NLCs被制成一种乳化基,并进行了体外释放,皮肤透和保留研究.
主要成果:
- 与单独的Cur相比,Cur:EGCG组合显示出显著增强的抗氧化活性.
- 该配方显示出强大的抗衰老作用,包括SIRT1刺激和抑制原酶和弹性酶.
- 对于Cur和EGCG,NLC实现了高捕获效率 (>98%).
- 乳化剂配方在48小时内持续释放Cur和EGCG,并在24小时后显著保留皮肤.
结论:
- 黄素和EGCG加载的NLCs在乳化基中代表了抗衰老的有前途的局部输送系统.
- 该配方增强了皮肤透,提供了持续的分娩,并且与单一化合物相比表现出优越的抗衰老活性.
- 这种先进的配方优化了皮肤病应用中的天然抗衰老剂的治疗潜力.
相关概念视频
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...