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Updated: May 21, 2025

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach
11:11

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Published on: February 21, 2019

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探索化内英多尔MC11的生物潜力及其与蛋白质激酶CK2的相互作用

Christelle Marminon1, Christian Werner2, Alexander Gast3

  • 1Small Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, University of Lyon, F-69373 Lyon, France.

Biological chemistry
|March 21, 2025
PubMed
概括

针对蛋白激酶CK2的多化化合物在瘤学中显示出显著的治疗潜力. 将四种素引入一个新的支架产生了MC11,这是一个强大的抑制剂,对白血病细胞有很强的活性.

关键词:
在 CK2α 中.在CK2α′中,共同结晶的情况.二[1,2-b]二醇的使用方法白血病细胞 细胞 白血病细胞蛋白质激酶 CK2 的作用.

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