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相关概念视频

Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Hazard Ratio01:12

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The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
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Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
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相关实验视频

Updated: Apr 14, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
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使用转录组数据和基于关键特征的基因组评估人类健康危害的工作流程.

Han-Hsuan D Tsai1,2, King David Oware3, Fred A Wright1,4,5

  • 1Interdisciplinary Faculty of Toxicology, Texas A&M University, College Station, Texas, 77843, USA.

Toxicological sciences : an official journal of the Society of Toxicology
|March 21, 2025
PubMed
概括

本研究引入了一种使用关键特征 (KCs) 的新计算方法,以改进用于化学危害识别的转录组数据的解释. 通过将KC映射到基因组中,研究人员可以更好地了解化学毒性机制.

关键词:
基因表达 基因表达基因组丰富 基因组丰富关键的特征 关键的特征文字转录学 (Transcriptomics) 是一个学科.

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科学领域:

  • 毒素基因组学 毒素基因组学
  • 计算生物学 计算生物学
  • 化学危险识别 化学危险识别

背景情况:

  • 用于危险识别的转录学数据分析面临着由于路径冗余和复杂解释的挑战.
  • 关键特征 (KCs) 对于理解化学品对健康的危害至关重要,但需要与转录基因数据进行更好的整合.

研究的目的:

  • 开发和验证一种用于与基因组交叉映射KC的计算方法,以提高毒基因组数据的解释性.
  • 改进化学危险识别的系统审查过程,使用集成的转录和KC数据.

主要方法:

  • 总结了72个KC成34个总体术语,并映射了来自Reactome和KEGG的基因组,以创建"KC基因组".
  • 通过使用公开的,二氧化物,苏尼提尼和阿莫西西林的转录基因数据集评估了KC基因组的性能.
  • 评估了与已知的化学机制和毒性相关的KC术语的丰富性.

主要成果:

  • KC基因组显示了Reactome和KEGG映射之间的最小重叠和互补性.
  • 丰富分析成功地确定了与测试毒素 (,二氧化物,苏尼提尼布) 的机制相关的KC术语.
  • 负对照 (阿莫西西林) 显示出有限且边际显著的丰富度,验证了方法的特异性.

结论:

  • 与基因组交叉映射KC提供了一个强大的计算方法来改善毒基因组数据的解释.
  • 这种方法有助于更透明和系统地识别化学品的危险.
  • 开发的KC基因组是监管科学和毒理学研究的宝贵工具.