一个混合纳米粒子同时消除癌症干细胞并激活STING途径,以潜在的癌症免疫疗法
Yaping Wu1, Pengfei Diao1, Yayun Peng2
1Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Nanjing Medical University; State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, P. R. China.
ACS nano
|March 21, 2025
概括
这项研究开发了新的纳米颗粒来对抗头癌. 这些纳米粒子消除癌症干细胞并激活cGAS/STING通路,提高免疫治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 纳米技术 纳米技术
- 免疫治疗是一种免疫疗法.
背景情况:
- 像免疫检查点阻塞 (ICBs) 这样的免疫疗法在头部和部状细胞癌 (HNSCC) 中表现出有限的疗效.
- 治疗耐药的癌症干细胞 (CSC) 和不足的循环氨酸单酸-氨酸单酸合成/干扰基因刺激 (cGAS/STING) 途径激活有助于HNSCC的免疫逃避和治疗耐药性.
研究的目的:
- 开发一种用于HNSCC治疗的纳米复合物,可以同时根除CSC并激活STING通路.
- 为增强HNSCC治疗创造一种新的纳米粒子配方.
主要方法:
- 通过绿色工艺合成PTC209/MnO2@BSA (牛血清白蛋白) 纳米颗粒 (PMB NPs).
- 研究了释放的 (Mn) 离子在增强cGAS-STING信号传递和树突细胞成熟中的作用.
- 评估了通过释放的PTC209对BMI1+ CSC的向,以抑制干性,上皮层-介质细胞过渡 (EMT) 和诱导亡.
- 评估了PMBNP在体外和体外的疗效.
主要成果:
- 在酸性瘤微环境中,PMBNP有效释放Mn离子,增强cGAS-STING信号并促进T细胞反应.
- PTC209释放抑制了CSC干和EMT,诱导了亡并加强了基于Mn的金属免疫疗法.
- PMB NPs显示出显著的治疗效果,抑制了HNSCC的生长和转移.
- 使用PMBNP和抗PD-1ICB的联合治疗显示出增强的抗瘤活性.
结论:
- 通过金属免疫疗法结合CSC消除和STING激活,PMBNP为HNSCC治疗提供了一个有前途的策略.
- 这种方法增强了现有的免疫疗法,如抗PD-1 ICB的疗效.
- 开发的纳米粒子代表了克服HNSCC耐药性的新治疗途径.
相关概念视频
Cancer Stem Cells and Tumor Maintenance
4.7K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.7K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Mesenchymal Stem Cells
4.6K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.6K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Tumor Immunotherapy
454
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
454
Cancer Vaccines
313
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
313


