沙门氏菌 (Salmonella enterica) 血清菌Braenderup显示了类特异性源协会和高比例的分子流行病学聚类
Harleen K Chaggar1, Lauren K Hudson1, Kelly Orejuela2
1Department of Food Science, University of Tennessee, Knoxville, Tennessee, USA.
Applied and environmental microbiology
|March 21, 2025
概括
沙门氏菌 (Salmonella enterica serovar Braenderup) 菌株形成了两个与不同的环境相关的不同的分类,如农产品和家禽. 这种基因组分析显示,与疫情相关的隔离物比以前估计的更多,有助于公共卫生监测.
科学领域:
- 基因组学和分子流行病学
- 食品传播病原体监测监测
- 微生物生态与适应 微生物生态与适应
背景情况:
- 沙门氏菌 (Salmonella enterica serovar Braenderup) 在美国是一个重要的临床病原体,经常与农产品和动物产品有关.
- 由于有限的基因组相关性分析,以前的与爆发相关的隔离物估计可能低估了真实比例.
研究的目的:
- 来自美国东南部的人类临床分离物的基因组相关性与全球临床和非临床的Salmonella enterica serovar Braenderup分离物进行比较.
- 调查种群结构,并确定类特定的环境关联和沙门氏菌 Enteric Serovar Braenderup 的潜在爆发集群.
主要方法:
- 从NCBI和EnteroBase获得的临床和非临床Salmonella enterica血清Braenderup分离物 (n=9,508) 的全基因组序列的遗传学分析.
- 利用cgMLST (核心基因组多部位序列类型) 来定义人口结构和识别分子流行病学集群.
- 统计分析以确定分类和环境来源 (产品,家禽,水,土壤,沉积物) 之间的重要关联.
主要成果:
- 在单个cgMLST eBurst组 (ceBG 185) 中,Salmonella enterica 血清菌 Braenderup 形成了一个单一的单一群.
- 确定了两个不同的分类:分类I与农产品和水/土壤/沉积物有显著的关联,分类II与家禽环境有显著的关联.
- 遗传学分析确定了218个分子流行病学群,表明与疫情相关的潜在隔离物比以前识别的比例更高.
结论:
- 基因组多样性分析揭示了Salmonella enterica serovar Braenderup的不同类别特定的环境关联,为传播途径提供了洞察力.
- 鉴定了众多分子流行病学集群,突出了大规模爆发的可能性,并强调了加强监测的必要性.
- 了解这些基因组模式和环境联系可以改善控制沙门氏菌 (Salmonella enterica serovar Braenderup) 感染的公共卫生战略.
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