在LGI1和CASPR2边缘脑炎中逆行性失忆症:两个病例报告和一个系统文献综述
Malvaso Antonio1,2, Denise Cerne3, Bernini Sara4
1Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
European journal of neurology
|March 21, 2025
概括
在与电压通道复杂抗体 (VGKC) 相关的边缘性自身免疫脑炎 (LAE) 中,孤立逆行性失忆症很少见,特别是CASPR2-LAE. 这种罕见的表现与认知恢复不良有关,需要进一步调查.
科学领域:
- 神经免疫学 神经免疫学
- 认知神经科学 认知神经科学
背景情况:
- 边缘性自身免疫脑炎 (LAE) 经常表现为前进性和逆向性失忆症.
- 针对电压通道 (VGKC) 复合体的抗体,特别是CASPR2和LGI1,是LAE的常见原因.
- 孤立的逆行性失忆症,没有其他认知缺陷,在LAE中非常罕见.
研究的目的:
- 描述CASPR2-LAE的两个新病例,呈现出孤立的逆行性失忆症.
- 系统地审查LAE与逆行性失忆症病例的文献,重点关注VGKC复杂抗体.
- 调查LAE中孤立逆行性失忆症的患病率和临床特征.
主要方法:
- 两名患有CASPR2-LAE和孤立逆行性失忆症的患者的病例报告.
- 按照PRISMA指南进行系统的文献审查.
- 分析涉及LAE,VGKC复合抗体 (LGI1,CASPR2) 和记忆障碍的研究.
主要成果:
- 在467名患有VGKC复合抗体和LAE的患者中,有14名 (2.9%) 患有逆行性失忆症,通常伴有逆行性失忆症.
- 报告的两个CASPR2-LAE病例是唯一的孤立逆行性失忆症 (0.4%).
- 反向性失忆症,特别是当孤立时,与大多数患者的有限认知改善有关.
结论:
- 逆行性失忆症是VGKC复杂抗体相关的LAE的一个未被认可的症状.
- 孤立逆行性失忆症扩大了CASPR2-LAE的临床谱.
- 这些发现强调了在自身免疫性脑炎中研究逆行性失忆症的重要性,并表明了对其病理生理学的潜在见解.
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