相关实验视频

Updated: May 21, 2025

Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies

Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies

Published on: May 22, 2020

23ME-01473,一种Fc效应器增强的抗ULBP6/2/5抗体,通过NKG2D和FcγRIIIa激活恢复NK细胞介导的抗瘤免疫力

Joel S Benjamin¹, Abigail Jarret¹, Shashank Bharill¹

¹23andMe, Inc. Therapeutics, South San Francisco, California.

Cancer research communications

|March 21, 2025

概括

研究人员确定了ULBP6作为癌症免疫治疗中的新目标. 针对ULBP6的抗体恢复了免疫细胞的激活,显示出治疗各种癌症的前景.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

免疫检查点抑制剂在癌症治疗方面取得了先进的进展,但许多患者没有受益.
需要新的治疗点来提高癌症免疫疗法的疗效.
NKG2D通路对于抗瘤免疫非常重要.

研究的目的:

研究UL16结合蛋白6 (ULBP6) 在癌症中的作用.
探索ULBP6作为潜在的免疫瘤治疗点.
开发和评估一种针对ULBP6.6的抗体.

主要方法:

利用大规模的人类生殖系遗传和健康数据库.
在人类瘤中确认ULBP6表达.
开发了一个人性化的Fc效应增强抗体 (23ME-01473),针对ULBP6,ULBP2和ULBP5.
评估了抗体阻断可溶性ULBP6-介导免疫抑制和诱导抗体依赖细胞细胞毒性 (ADCC) 的能力.

主要成果:

可溶性ULBP6通过绕过NKG2D激活来抑制免疫细胞激活和瘤细胞杀死.
抗体23ME-01473有效地阻断可溶性ULBP6的免疫抑制作用.
23ME-01473恢复NKG和T细胞上的NKG2D通路激活,控制瘤生长.
抗体的Fc效应增强通过FcγRIIIa参与促进ADCC诱导.

结论:

ULBP6在癌症免疫逃避中发挥着重要作用.
用Fc效应增强抗体准ULBP6可以重振抗瘤免疫力.
这种方法显示了通过增强NK和T细胞活性来治疗癌症的治疗潜力.

更多相关视频

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

Published on: July 12, 2018

相关概念视频

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...