喉科的实践趋势:神经调节剂用于治疗慢性咳
Christopher D Dwyer1, Michael M Johns2, Jennifer J Shin1
1Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Brigham & Women's Hospital, Boston, Massachusetts, USA.
The Laryngoscope
|March 21, 2025
概括
喉科医生广泛使用神经调节剂,主要是 gabapentin 和 amitriptyline,用于慢性咳. 治疗包括滴定,如果咳复发,很有可能重新开始有效的药物治疗.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性咳是一种使人衰弱的疾病,影响生活质量.
- 神经调节剂越来越多地用于耐火和无法解释的慢性咳.
- 了解当前的实践模式对于优化治疗策略至关重要.
研究的目的:
- 评估美国喉科医生关于使用神经调节剂治疗慢性咳的现有实践趋势.
- 确定最常被处方的神经调节剂及其在慢性咳管理中的一线应用.
主要方法:
- 一项匿名的29项电子调查被分发给美国各地的喉科医生.
- 该调查包括多项选择,利克尔特比例和自由文本问题,以收集全面的数据.
- 来自26个州的85名喉科专家参与了调查.
主要成果:
- 绝大多数 (96.5%) 的喉科医生为慢性咳开处方神经调节剂.
- gabapentin (97.6%), amitriptyline (91.5%),和特拉马多尔 (73.2%) 是最常用的神经调节剂.
- 神经调节剂是耐火解释性慢性咳 (37.8%) 和不解释性慢性咳 (50.6%) 的首选一线治疗方法.
结论:
- 神经调节剂经常被喉科医生用于无法解释和不耐药的慢性咳.
- gabapentin 和 amitriptyline 是首选的一线药物,需要仔细定位以平衡疗效和副作用.
- 如果咳复发,重新启动以前有效的神经调节剂或考虑其他治疗方法,如上喉神经 (SLN) 阻塞,这一门很低.
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