克洛托调解血清丸激素与严重腹腔大动脉化之间的关联:来自NHANES数据库的横截面研究
Shengwei Lai1,2, Handai Qin1, Xinhao Wang2
1Medical School of Chinese PLA, Beijing, 100853, China.
Naunyn-Schmiedeberg's archives of pharmacology
|March 21, 2025
概括
高血清丸激素水平与严重腹腔大动脉化 (SAAC) 的风险降低有关. 这种关联是由抗衰老蛋白Klotho调解的,提供了潜在的治疗见解.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 严重的腹腔大动脉化 (SAAC) 显著导致心血管疾病.
- 性类固醇激素和SAAC之间的关系尚不清楚.
- 调查与SAAC的荷尔蒙联系对于了解心血管风险至关重要.
研究的目的:
- 探索血清性类固醇激素水平与SAAC之间的关联.
- 确定激素与SAAC之间的关系中的潜在调解因素.
- 提供关于SAAC的预防和治疗的见解.
主要方法:
- 利用了来自2013-2014年队列的国家健康和营养检查调查 (NHANES) 的数据.
- 评估SAAC使用腹腔大动脉化24点级.
- 采用多变量逻辑回归,子组分析,约翰逊-尼曼图形和调解分析.
主要成果:
- 较高的血清丸激素水平与SAAC风险相反相关 (AOR=0.33).
- 这种关联在60岁以上的个体和非高血压参与者中更为明显.
- 性激素结合环球蛋白显示出值效应,而Klotho则调解了-SAAC链接.
结论:
- 血清丸激素与SAAC相反地相关.
- 抗衰老蛋白Klotho在这种关联中起着调解作用.
- 研究结果表明,针对性激素和Klotho用于SAAC预防的潜在治疗策略.
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