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颗粒物2.5与甲状腺功能和甲状腺癌之间的关联:一个元分析
Haihong Wang1, Jing Xu1, Caizhu Huang2
1Department of Gynaecology and Obstetrics, 900 Hospital of the Joint Logistics Team, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, 365000, China.
概括
暴露于细颗粒物 (PM2.5) 显著增加甲状腺功能低下的风险,并对甲状腺激素如TSH和FT4产生负面影响. 孕妇特别容易受到这些影响,强调减少PM2.5暴露的必要性.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 不一致的流行病学发现将大气颗粒物2.5 (PM2.5) 暴露与甲状腺功能障碍联系起来.
- 了解PM2.5对甲状腺功能的影响对于公共卫生至关重要.
- 与PM2.5暴露相关的甲状腺癌风险需要进一步调查.
研究的目的:
- 对PM2.5暴露与甲状腺功能之间的关联进行系统审查和元分析.
- 澄清PM2.5水平与甲状腺功能障碍风险之间的关系.
- 评估PM2.5对甲状腺癌风险的影响.
主要方法:
- 在科学网,Embase,Cochrane图书馆和PubMed的系统文献搜索,直到2024年4月.
- 包括来自1322个收集文章的27项研究.
- 对PM2.5暴露数据和甲状腺功能标志物 (TSH,FT4) 的元分析.
主要成果:
- 暴露于PM2.5是甲状腺功能低下症的重要危险因素 (发病率风险增加0.15).
- 亚洲人群中较高的PM2.5水平与增加的TSH和减少的FT4.4相关.
- 在怀孕期间增加的PM2.5暴露与TSH升高和FT4.4降低有关.
结论:
- 暴露于PM2.5被证实是甲状腺功能下降的危险因素.
- 亚洲人群中的高PM2.5水平显著影响甲状腺激素 (TSH,FT4).
- 在怀孕期间监测和减少PM2.5暴露对于减轻甲状腺功能障碍风险至关重要.
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