基于风险和密度的个性化查:来自RIBBS研究的流行数据.
Francesca Caumo1, Gisella Gennaro2, Alessandra Ravaioli3
1Breast Radiology Unit, Department of Imaging and Radiotherapy, Veneto Institute of Oncology (IOV) IRCCS, Via Gattamelata 64, 35128, Padua, Italy.
La Radiologia medica
|March 21, 2025
概括
基于风险的乳腺查 (RIBBS) 研究表明,使用数字乳腺瘤合成 (DBT) 的个性化方法可以识别高风险女性的乳腺癌 (BC) 患病率. 这种量身定制的查策略是可行的,并确定了针对性查的特定亚群.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 目前乳腺癌 (BC) 查指南经常使用一种适合所有人的方法.
- 个性化查模型旨在优化检测并减少过度诊断.
- 数字乳腺图解合成 (DBT) 提供了更好的可视化密集的乳腺组织.
研究的目的:
- 评估基于风险的乳腺查 (RIBBS) 研究的流行查结果.
- 评估一个使用DBT的个性化查模型,用于45-49岁的女性.
- 为了比较先进的BC发病率减少与量身定制的查与年度乳房镜相比.
主要方法:
- 在干预队列中招募了10,269名45岁的女性 (2020年1月至2021年12月).
- 使用DBT和BC风险问卷来分类风险分层到五个子组.
- 与43,838名接受年度数字乳房镜检查 (DM) 的女性的对照队列进行了查性能比较.
主要成果:
- 与低风险,低密度 (LR-LD) 相比,中等风险组 (IR-LD,IR-HD) 的BC患病率明显高 (4.9和4.6倍).
- 在中等风险组中观察到pT1c瘤的更高患病率 (7.1倍).
- 干预队列的召回率较低 (0.5),但DCIS (2.9),pT1c (2.3) 和3级瘤 (2.4) 的患病率增加.
结论:
- 患病率查证实了DBT和补充超声波 (US) 在高密度子组中的可行性.
- 分层标准有效地识别了具有不同BC流行率的子群体.
- 增加早期瘤 (pT1c) 的检测是必要的,但不足以减少晚期BC发病率.
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