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Updated: May 21, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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Published on: July 20, 2019

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DNMT1抑制将T细胞重新编程为具有强烈抗瘤活性的NK类细胞

Yao Li1,2, Jiongliang Wang1,2, Linfu Zhou1

  • 1China-New Zealand Joint Laboratory on Biomedicine and Health, National Key Laboratory of Immune Response and Immunotherapy, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

Science immunology
|March 21, 2025
PubMed
概括

不活化BCL11B将T细胞重新编程成NK类细胞. DNMT1和像EZH2这样的表观遗传修饰剂保持T细胞的身份,它们的抑制增强了NK类细胞重编程和免疫治疗的抗瘤作用.

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