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Updated: May 21, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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CD38介导的代谢重编程促进了瘤中调节性T细胞的稳定性和抑制功能

Ishita Sarkar1,2, Debashree Basak1,2, Puspendu Ghosh1,2

  • 1Division of Cancer Biology and Inflammatory Disorder, IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.

Science advances
|March 21, 2025
PubMed
概括

瘤中的调节性T细胞 (Tregs) 通过CD38适应新陈代谢,耗尽NAD+. 用CD38抑制剂向这一轴会破坏Tregs的稳定,增强抗瘤免疫力.

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