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在上肢外科手术中通过区域输液与静脉预防实现的万科米辛组织度:随机对照试验
Nathaniel B Hinckley1, Molly C Klanderman1, Kevin J Renfree1
1Department of Orthopaedic Surgery, Mayo Clinic Arizona, Phoenix, AZ.
The Journal of hand surgery
|March 21, 2025
概括
与系统注射相比,在上肢的区域静脉输液中输注万科米会在骨和软组织中产生显著更高的抗生素度. 这种方法在预防和治疗上肢感染方面表现有前途.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 之前的研究表明,在下肢骨内注射时,万科米辛的组织度更高.
- 系统性静脉注射万科米辛需要更高的剂量,以达到可比的组织水平.
研究的目的:
- 量化和比较手和手腕骨和软组织中的万科米辛度.
- 为了评估区域性输液与系统性给药对上肢木素的输送.
主要方法:
- 接受上肢骨切除的20名患者被随机分配,接受区域性静脉输液 (125毫克) 或系统性静脉输液 (1克) 范科米.
- 骨和皮下脂肪样本是在切口后的多个时间点收集的.
- 主要结局是组织度的差异;次要结局包括并发症.
主要成果:
- 区域性输液导致脂肪 (114.9150.1 μg/g) 和骨 (107.0117.4 μg/g) 的平均度明显高于系统性输液 (脂肪:3.95.2 μg/g;骨:13.014.9 μg/g).
- 一个装配的线性混合模型显示,区域输液的平均组织度高于109μg/g.
- 在12周的随访期间,在两组中都没有观察到需要重新手术的并发症.
结论:
- 与系统注射相比,在上肢的区域静脉输液中输入万科米可以在骨和软组织中达到更高的抗生素度.
- 这种方法需要进一步研究,以预防和治疗上肢感染.
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