多层次干预以支持在北卡罗来纳州农村地区的量身定制和响应性艾滋病毒暴露前预防护理:随机对照试验协议
Sarah E Rutstein1, Ella Ferguson2, Odai Mansour1
1Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
JMIR research protocols
|March 21, 2025
概括
这项研究测试了一种数字健康干预措施,以增加北卡罗来纳州农村地区服务不足人群的暴露前预防 (PrEP) 吸收率. 目标是通过改善获得艾滋病毒预防服务来减少艾滋病毒差异.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 数字健康干预措施 数字健康干预措施
背景情况:
- 美国南部仍然存在艾滋病毒预防差异,北卡罗来纳州在年轻人,性少数群体和性别少数群体中暴露前预防 (PrEP) 吸收率较低.
- 准备与需要的比率突出显著的不平等,服务不足的群体,如妇女和黑人,西班牙裔和南方人与艾滋病毒发病率相比,获得的机会较低.
- 医疗保健基础设施有限,PrEP服务集中在城市的性传播疾病诊所,造成了农村地区预防艾滋病毒的障碍.
研究的目的:
- 描述一种随机对照试验协议,用于多层次的PrEP干预.
- 为了解决北卡罗来纳州农村和郊区环境中PrEP吸收的差异.
主要方法:
- 这是一项随机对照试验,招募了336名参与者,分为1:1的干预或对照组.
- 干预包括数字健康应用程序,远程PrEP导航器连接和远程医疗选择;对照组接受了增强的标准护理.
- 主要结果是在3个月内启动PrEP;次要结果包括护理参与,坚持,事件感染,耻辱和成本效益.
主要成果:
- 招生于2023年8月在15个北卡罗来纳州卫生部门开始,到2024年7月扩展到21个设施.
- 预计数据收集将于2025年5月结束,结果将在此后公布.
- 该研究已在临床试验.gov (NCT05984030) 上注册.
结论:
- 这项研究直接解决了美国东南部服务不足的农村和郊区PrEP使用的障碍.
- 调查结果可以为政策和规划提供信息,以扩大PrEP获取范围,并在面临艾滋病毒差异的社区中促进其使用.
- 该干预旨在改善PrEP公平性,并减少弱势群体的艾滋病毒发病率.
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