内巴克洛芬治疗药物耐药性一般化二次性 dystonia 的长期结果
Joyce Koueik1, Tenzing Lhamo1, Emily Meyer1
11Department of Neurological Surgery, University of Wisconsin-Madison, Wisconsin; and.
Journal of neurosurgery. Pediatrics
|March 21, 2025
概括
腹腔内巴克洛芬 (IVB) 提供了一种安全有效的长期治疗一般化二次性 dystonia. 这项研究显示,对 dystonia 症状的显著改善,并发症率与静脉内巴克洛芬 (ITB) 相当.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 内巴克洛芬 (ITB) 是二次通用性 dystonia 的标准治疗方法.
- 腹腔内巴克洛芬 (IVB) 是一种潜在的更安全的替代品,并没有太多的并发症.
- 需要进一步调查IVB治疗的长期结果.
研究的目的:
- 评估内巴克洛芬 (IVB) 的长期疗效和安全性,用于治疗二次泛性 dystonia.
- 为了比较IVB的并发症率与ITB的并发症率.
主要方法:
- 从2005年4月到2024年6月接受IVB治疗的患者的回顾性分析.
- 纳入标准:至少有1年的随访和IVB in situ的患者.
- 收集的数据: dystonia 病因,功能评分 (BADS,Ashworth),并发症和随访时间.
主要成果:
- 包括27名患有二次通用性 dystonia (78%脑) 的患者 (平均年龄为12.9岁).
- 在巴里-阿尔布赖特 dystonia 尺度 (BADS) 和阿什沃思尺度得分中观察到显著改善.
- 并发症包括感染 (4%),伤口脱光 (4%) 和水 (15%),需要转移脊髓.
结论:
- 腹腔内巴克洛芬 (IVB) 耐受性良好,有效治疗对其他治疗不耐药的泛性二次 dystonia.
- 长期结果是积极的,与显著的 dystonia 改善.
- 在IVB中,并发症的发生率与内巴克洛芬 (ITB) 类似.
更多相关视频
相关概念视频
Skeletal Muscle Relaxants: Therapeutic Uses
448
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
448
Drug Delivery: Parenteral Route
355
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
355
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
642
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
The binding of dantrolene to the RYR1...
642
Skeletal Muscle Relaxants: Adverse Effects
327
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
327
Peripherally and Centrally Acting Muscle Relaxants: A Comparison
3.1K
Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
3.1K
Classification of Skeletal Muscle Relaxants
2.3K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
2.3K


