从一个健康的角度来看,酵母中的抗真菌耐药性:一项巴西研究
Rafael Wesley Bastos1, Nalu Teixeira de Aguiar Peres2, Kássia Jéssica Galdino da Silva3
1Departamento de Microbiologia e Parasitologia, Centro de Biociências, Federal University of Rio Grande do Norte, 3000 Sen. Salgado Filho Avenue, Natal, RN 59064-741, Brazil; Brazilian National Institute of Science and Technology in Human Pathogenic Fungi, Brazil.
The Science of the total environment
|March 21, 2025
概括
在巴西的临床,动物和环境样本中观察到Candida酵母的抗真菌耐药性,包括Candida tropicalis,Candida glabrata和Candida albicans. 临床抗真菌药物和环境杀菌剂 (如特布可纳) 之间的交叉耐药性是令人担忧的.
科学领域:
- 医学真菌学 医学真菌学
- 抗微生物耐药性 抗微生物耐药性
- 环境微生物学 环境微生物学
背景情况:
- 环境杀剂暴露可能导致真菌的交叉耐药性.
- 有限的数据存在于环境抗真菌剂对医学上重要的酵母如Candida的影响.
- 坎迪达菌种是人类感染的重要原因,需要了解它们的耐药性模式.
研究的目的:
- 调查来自巴西不同来源的Candida分离物的抗真菌耐药性.
- 评估临床和环境抗真菌剂对Candida耐药性的影响.
- 为了探索临床抗真菌药物和环境中醇tebuconazole之间的潜在交叉耐药性.
主要方法:
- 多中心研究收集了来自巴西四个州的患者,医院,动物 (猪,家禽) 和环境的571个酵母分离物.
- 针对抗菌敏感性测试 (AFST) 进行了可纳,米卡丁和B.安福特.
- 确定了tebuconazole的最小抑制度 (MIC),并提出一个切断值来评估耐药性.
主要成果:
- 甘地达菌种包括82.5%的分离物. 热带虫 (Candida tropicalis) 呈现出最高的可纳耐药性 (12%),其次是C. glabrata (8%) 和C. albicans (6%).
- 在C. glabrata (15%) 中,米卡金耐药性最高. 确定了两种非野生类型的安福特乙分离物 (C. tropicalis,C. glabrata).
- 在临床,动物和环境隔离物中发现了耐药性. 10.5%的隔离物具有高的特布可纳MIC,3.6%对可纳和特布可纳呈现交叉耐药性.
结论:
- 在巴西,Candida的抗真菌耐药性存在于临床,动物和环境环境中.
- 环境杀菌剂,如特布可纳,可能会导致与临床醇的交叉耐药性,特别是Candida albicans,Candida tropicalis和Candida krusei.
- 监测酵母耐药性和采用多学科方法对于理解和管理抗真菌耐药性发展至关重要.
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