乙--环 (Eco-DEHCH) 是一种更安全的酸盐替代品,不引起神经内分泌干扰效应
Jiyun Kang1, Cong Minh Tran1, Handule Lee2
1Department of Environmental Engineering, Seoul National University of Science and Technology, Seoul 01811, South Korea.
甲基-基-环素 (DEHCH) 的内分泌干扰作用低于常规酸盐 (CPs) 和其他替代酸盐 (APs). 这种新的替代性酸盐并没有影响斑马鱼幼虫的基因表达或神经行为.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 传统的酸盐 (CPs) 构成健康风险,导致替代酸盐 (APs) 的开发.
- APs的安全性和内分泌干扰 (ED) 潜力,包括新的化合物,如二甲基-基-环素 (DEHCH),需要进行彻底的调查,以确定它们是否可以安全地取代CP.
研究的目的:
- 评估二甲基-基-环素 (DEHCH) 的内分泌干扰潜力.
- 为了比较DEHCH的安全性与常规酸盐 (DEHP,DINP) 和其他替代酸盐 (DINCH,DEHTP) 的安全性.
主要方法:
- 在基分子对接模拟中评估受体结合亲缘关系.
- 在体外基于细胞的测试检查雌激素和雄激素受体活性.
- 使用斑马鱼胚胎进行体内研究,以分析基因表达,神经行为和神经类固醇水平.
主要成果:
- 与其他测试的甲酸盐相比,DEHCH对关键内分泌受体的结合亲和力较低.
- 对于任何测试的甲酸盐,没有观察到雌激素或雌激素活性.
- DEHCH没有影响斑马鱼的内分泌相关基因表达或神经行为,与DINCH,DEHP和DEHTP不同,它们诱导过度活跃并改变了基因表达.
结论:
- 与传统甲酸盐和其他替代甲酸盐相比,甲基-甲基-环素 (DEHCH) 在内分泌干扰方面表现出更安全的特征.
- 在斑马鱼中,DEHCH似乎不会引起神经行为或基因表达变化,这表明神经系统调节失调的风险降低了.
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