环境多环芳和心血管疾病在中国
Yaohua Tian1, Jing Zhang2, Cuiyuan Huang2
1Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Key Laboratory of Ischemic Cardiovascular Disease, Yichang, China.
暴露于多环芳 (PAH) 增加了心血管疾病的住院病例. 这些空气污染物通过炎症和氧化应激导致心脏损伤,即使考虑到PM2.5.5.之后.
科学领域:
- 环境健康 环境健康
- 心血管医学 心血管医学
- 毒理学 毒理学 毒理学
背景情况:
- 多环芳 (PAHs) 是广泛存在的空气污染物,在环境水平上对健康的影响知之甚少.
- 心血管疾病 (CVD) 构成了全球严重的健康负担.
- 调查环境PAH和心血管疾病住院治疗之间的联系对公共卫生至关重要.
研究的目的:
- 检查环境多环芳 (PAHs) 与每日因心血管疾病住院治疗之间的关联.
- 探索PAHs与心脏损伤之间的关系背后的潜在机制.
主要方法:
- 在中国184个城市 (2014-2017) 进行了一项全国性的观测研究,使用时间序列准松回归和元分析.
- 一项实验性动物研究涉及通过气管灌注暴露于PAHs的小鼠.
- 转录基因和蛋白质基因测序以阐明潜在的机制.
主要成果:
- 在PAHs的四分位数间范围的增加与心血管疾病住院病例的5.18%的增加有关,独立于PM2.5.5.
- 在社会经济地位较低,温度/湿度较高的地区以及老年人群中,相关性更强.
- 动物研究证实PAHs通过炎症和氧化应激诱导心脏损伤,可能涉及PI3K/AKT和MAPK通路.
结论:
- 环境多环芳 (PAHs) 是心血管疾病的一个明显的风险因素.
- 通过调节炎症和氧化应激,PAHs有助于心脏损伤.
- 这些发现强调了需要制定策略,以减轻PAH暴露对心血管健康的影响.
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