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Updated: May 21, 2025

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在抑郁症中经过重复的横磁刺激后的结构变化以及与神经递质配置文件的联系

Liangliang Ping¹, Zhaosong Chu², Biao Zhou³

¹Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China; Department of Psychiatry, Xiamen Xianyue Hospital, Xiamen, Fujian 361000, China; Xianyue Hospital Affiliated with Xiamen Medical College, Xiamen, Fujian 361000, China; Fujian Psychiatric Center, Xiamen, Fujian 361000, China; Fujian Clinical Research Center for Mental Disorders, Xiamen, Fujian 361000, China.

Asian journal of psychiatry

|March 21, 2025

概括

重复性跨体磁性刺激 (rTMS) 通过增加前边缘网络中的灰质来改善抑郁症. 这种结构变化与多巴胺D1受体有关,这表明rTMS抗抑郁作用的神经生物学基础.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
神经成像是一种神经成像.

背景情况:

重复性跨磁刺激 (rTMS) 是一种常见的抑郁症治疗方法,其神经生物学机制尚不清楚.
了解rTMS如何影响大脑结构和神经递质对于优化治疗至关重要.

研究的目的:

调查rTMS对患有严重抑郁症 (MDD) 患者大脑结构的影响.
探索在rTMS治疗后的大脑结构变化和神经递质系统之间的关系.

主要方法:

一个双盲,假控制试验,涉及36名MDD患者,他们接受活跃或假rTMS,针对背侧前额皮层 (DLPFC) 3周.
评估使用汉密尔顿抑郁症评分尺度-17 (HAMD-17) 的抑郁症状,并通过神经成像分析灰色物质变化.
灰质变化与神经递质受体/输送体分布之间的相关性分析.

主要成果:

活跃和假的rTMS都改善了抑郁和焦虑症状,活跃组的疗效更大.
活跃的rTMS导致前边缘网络的灰质体积增加.
灰质变化与D1受体的空间分布有显著的相关性.

结论:

针对左侧DLPFC的rTMS增强了前边缘网络的结构性可塑性,有助于抗抑郁药的效果.
多巴胺系统调节,特别是涉及D1受体,可能是rTMS治疗抑郁症的治疗益处的基础.

关键词:

抑郁症抑郁症抑郁症灰色物质是一种灰色物质.神经递质神经递质在RTMS中使用RTMS.

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