通过氨基酸共接种的环氧金属有机框架,涂上大豆型多糖,通过对氨酸有反应的黄素输送

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Shumin Wang¹, Shengnan Wang², Xiuzhi Cao¹

¹College of Food Science and Technology, Bohai University, Jinzhou 121013, China.

|March 21, 2025

概括

一个新的大豆覆盖多糖的金属有机框架 (Cys-γ-CD-MOF@SHP) 能够有针对性的释放黄素. 这种新型载体提高了生物可用性,并减少了疏水化合物的副作用.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
药物运输药物运输药物运输

背景情况:

黄素 (Cur) 输送受到生物可用性差以及潜在副作用的限制.
开发有针对性的输送系统对于提高治疗疗效至关重要.
金属有机框架 (MOF) 由于其可调节的结构,具有作为药物载体的潜力.

研究的目的:

设计一种新的金属有机框架 (Cys-γ-CD-MOF) 用于谷 (GSH) 触发的黄素释放.
用大豆多糖化物 (SHP) 覆盖MOF,以提高生物可用性和减少副作用.
评估开发的载体系统的装载,封装和释放特性.

主要方法:

合成Cys-γ-CD-MOF及其随后的SHP涂层.
使用X射线衍射 (XRD) 和扫描电子显微镜 (SEM) 进行表征.
在优化条件下确定黄素加载和封装效率.
在实验室释放研究中,研究了GSH的存在和缺乏.

主要成果:

SHP涂层没有影响Cys-γ-CD-MOF的结晶性;SEM证实了立方形态.
在1:3的Cur-to-carrier比率下,达到51.99%的最大黄荷载和封装效率.
在GSH溶液中,Cys-γ-CD-MOF@SHP表明选择性黄素释放,在24小时内达到56.39%的累积释放.

结论:

Cys-γ-CD-MOF@SHP是一种有前途的载体,可以有针对性地提供黄素.
SHP涂层增强了生物可用性,并减少了潜在的不良影响.
该系统有可能提供其他疏水生物活性化合物.

关键词:

在Cys-γ-CD-MOF中使用.葡萄氨酸反应敏捷的释放动力学释放动力学在 SHP SHP 中.

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