ChREBP驱动纤维细胞的增殖,并促进肺纤维化发展
Jian Zheng1, Yang Zhang1, Yan Chen2
1Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, China.
Cytokine
|March 21, 2025
概括
碳水化合物敏感元素结合蛋白 (ChREBP) 在肺纤维化中被上调,促进纤维细胞的增殖和抑制亡. 向ChREBP可能为治疗这种疾病提供了一个新的治疗策略.
科学领域:
- 肺部医学 肺部医学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 肺纤维化 (PF) 是一种进展性肺病,其特征是细胞外基质沉积过多.
- 驱动PF病变的精确分子机制仍然不完全理解.
- 碳水化合物敏感元素结合蛋白 (ChREBP) 是一种转录因子,与代谢调节有关.
研究的目的:
- 调查ChREBP在肺纤维化病原发生中的作用.
- 评估ChREBP对纤维蛋白表达,纤维细胞增殖和肺组织的亡的影响.
主要方法:
- 在小鼠中的白素诱导的肺纤维化模型.
- 肺组织的组织病理学分析.
- 西方斑块和ELISA测量蛋白质表达 (包括ChREBP,TNF-α,MMP-7,TGF-β1).
- 使用人类胚胎肺纤维细胞 (MRC-5) 的体外研究,具有ChREBP过度表达或沉默.
主要成果:
- 肺纤维化模型表现出膜异常和炎症/纤维化标志物升高.
- 在纤维化肺组织中,ChREBP表达显著增加.
- 在体外,ChREBP过度表达促进了纤维细胞增殖和抑制了细胞灭绝,而ChREBP沉默则产生了相反的效果.
结论:
- 肺纤维化时ChREBP被上调,在促进纤维细胞增殖和抑制细胞亡方面发挥着关键作用.
- 准ChREBP为肺纤维化提供了一个潜在的新疗法策略.
- 调节ChREBP活性可能会影响与PF治疗相关的纤维化和亡途径.
相关概念视频
01:09Introduction to Fibroblasts
3.0K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.0K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:58Cell Specific Gene Expression
13.3K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.3K
01:24Chronic Pancreatitis I: Introduction
56
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
56
01:16TGF - β Signaling Pathway
7.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K