相关实验视频

Updated: Aug 4, 2026

Isolating and Using Sections of Bovine Mesenteric Artery and Vein as a Bioassay to Test for Vasoactivity in the Small Intestine

Isolating and Using Sections of Bovine Mesenteric Artery and Vein as a Bioassay to Test for Vasoactivity in the Small Intestine

Published on: October 7, 2014

在健康的马匹和有肠的马匹中,对称和不对称的二甲基氨酸

Francesca Bindi¹, Irene Nocera², Valentina Meucci¹

¹Department Veterinary Sciences, University of Pisa, Italy.

Research in veterinary science

|March 21, 2025

概括

对称二甲基氨酸 (SDMA) 和非对称二甲基氨酸 (ADMA) 的血度在患有的马中进行了分析. 两种生物标志物都没有有效地区分结肠类型或全身炎症反应综合征 (SIRS) 状态.

科学领域:

马类医学马类医学
生物标志物发现发现
兽医内科兽医内科

背景情况:

是马匹常见且可能危及生命的疾病.
系统性炎症反应综合征 (SIRS) 可以使结肠的情况复杂化.
确定可靠的结肠严重程度和类型的生物标志物对于有效治疗至关重要.

研究的目的:

为了研究对称二甲基氨酸 (SDMA) 和不对称二甲基氨酸 (ADMA) 的血度,在有的马中.
评估SDMA和ADMA水平和结肠类型 (窒息与非窒息) 之间的关系.
评估SDMA和ADMA与有系统性炎症反应综合征 (SIRS) 状态的相关性.

主要方法:

血SDMA和ADMA水平在多个时间点测量在健康的马匹和肠患者.
马匹根据结肠的类型,SIRS状态,治疗和结果进行分类.
统计分析包括克鲁斯卡尔-瓦利斯,弗里德曼测试和通用线性混合模型 (GLMM).
使用接收器操作特征 (ROC) 曲线评估诊断准确性.

主要成果:

与结肠病患者相比,健康马的SDMA度在健康马中明显较低.
在窒息性结肠和SIRS阳性马匹与健康对照群相比,ADMA水平在T2显著更高.
根据GLMM分析,SDMA或ADMA在结肠类型,SIRS状态,治疗或结局上没有显著差异.
ROC分析表明,SDMA和ADMA在区分结肠类型或SIRS状态方面的诊断实用性有限.

结论:

虽然SDMA和ADMA水平在健康和结肠酸马之间有所不同,但它们似乎不是可靠的生物标志物来区分结肠酸类型或SIRS状态.
可能需要进一步的研究来探索其他潜在的生物标志物用于马.

关键词:

ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA ADMA was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was that was was was was was was was was was was was was was was was was was was was was was was was that was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was 生物标志物生物标志物结肠是因为.SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SDMA SD 系统性炎症反应综合征

更多相关视频

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

Published on: October 4, 2024

相关概念视频

Carbohydrate Digestion

Carbohydrate Digestion

Carbohydrate digestion and metabolism break down simple and complex carbohydrates from food into saccharides (i.e., sugars) for the body to use as energy. Carbohydrate digestion starts in the mouth during mastication, or chewing. The masticated carbohydrates remain intact in the stomach. Digestion resumes in the duodenum of the small intestine, where pancreatic alpha-amylase and brush border enzymes of the microvilli convert complex carbohydrates to monosaccharides. Finally, the monosaccharides...

Animal Mitochondrial Genetics

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...

Amino Acid Catabolism

Amino Acid Catabolism

Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...

Probiotics

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...

Microbiota of the Stomach and Small Intestine

Microbiota of the Stomach and Small Intestine

The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...

Dysbiosis of the Gut Microbiota

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...