在多发性硬化症的门诊老年人中验证患者确定的疾病阶段
Robert C Leavenworth1, Mark E Wagshul2, Robert W Motl3
1Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA.
Multiple sclerosis and related disorders
|March 21, 2025
概括
患者确定的疾病阶段 (PDDS) 有效地测量了患有多发性硬化症 (MS) 的老年人的运动障碍. 这项研究证实了它与客观测试和神经成像标记器相比的有效性.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 老年病的医生 老年病的医生
背景情况:
- 多发性硬化症 (MS) 患病率在老年人中正在上升,加剧了与年龄相关的流动性下降.
- 患者确定的疾病阶段 (PDDS) 是患者报告的MS移动障碍的结果,但其在老年人中的有效性尚未确立.
- 这项研究旨在在老年多发性硬化患者群体中验证PDDS.
研究的目的:
- 验证患者确定的疾病阶段 (PDDS) 作为患有多发性硬化症 (MS) 的老年人运动障碍的衡量标准.
- 评估PDDS得分与客观功能测试,患者报告的结果和大脑完整性神经成像标记的相关性.
主要方法:
- 评估了87名患有多发性硬化症的老年人队列 (平均年龄为64.67岁).
- 这些措施包括定时25英尺步行 (T25FW),短时间体力表现电池 (SPPB),UAB生命空间评估 (UAB-LSA),九洞测试 (9HPT),疲劳严重程度量表 (FSS) 和口语符号数字模式测试 (口语SDMT).
- 使用3TMRI评估大脑完整性,评估灰质体积和白质病变负载 (WMLL). 使用了斯皮尔曼相关性.
主要成果:
- 较高的PDDS得分与步行速度较慢 (T25FW),下肢功能较差 (SPPB),精细运动敏捷性降低 (9HPT),疲劳增加 (FSS) 和社区流动性降低 (UAB-LSA) 有显著的相关性.
- 此外,PDDS得分还显示了与尾状体,面体和海马体灰色物质体积的显著反向相关性.
- 没有发现与白质病变负载 (WMLL) 或口服SDMT.有显著的相关性.
结论:
- 患者确定的疾病阶段 (PDDS) 是一个有效和可靠的患者报告的结果指标,用于评估患有多发性硬化症的门诊老年人的运动障碍.
- 这些发现支持在临床实践和涉及老年多发性硬化患者的研究中使用PDDS.
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