β-基酸盐促进了线粒体衍生的囊泡生物发生,并改善了线粒体功能
Min Tang1, Yingfeng Tu1, Yanqiu Gong2
1Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
Molecular cell
|March 21, 2025
概括
体β-酸 (BHB) 通过促进线粒体衍生囊泡 (MDV) 生物发生来增强线粒体功能. 这发生在对分类nexin-9 (SNX9) 的β-基基化过程中,这对细胞和生物健康至关重要.
科学领域:
- 细胞生物学 细胞生物学
- 代谢过程中的代谢.
- 线粒体生物学 线粒体生物学
背景情况:
- 线粒体动力学和代谢物是相互关联的.
- 线粒体衍生囊泡 (MDVs) 参与清除受损的线粒体组件.
- 代谢物在MDV生物发生中的作用在很大程度上是未知的.
研究的目的:
- 调查代谢物在MDV生成中的作用.
- 探索β-基酸盐 (BHB) 影响线粒体功能的机制.
- 为了确定BHB诱导的修饰对细胞和生物健康的影响.
主要方法:
- 研究了BHB对MDV生物发生的作用.
- 鉴定和描述了BHB (lysine β-hydroxybutyrylation, Kbhb) 对排序nexin-9 (SNX9) 的翻译后修改.
- 评估了SNX9 Kbhb在细胞和小鼠模型中的功能后果.
主要成果:
- 发现BHB有助于MDV生物发生,改善线粒体功能.
- BHB诱导了SNX9的lysineβ-hydroxybutyrylation (Kbhb),这是MDV生物发生的关键调节者.
- SNX9 Kbhb增强了SNX9与线粒体蛋白质的相互作用,促进了MDV的形成,并防止酒精诱导的肝损伤.
结论:
- 代谢物,特别是BHB,通过对SNX9.9等关键蛋白质的翻译后修饰来直接调节MDV的形成.
- 由BHB诱导的SNX9修饰对于维护线粒体平衡至关重要,并提供对肝损伤的保护.
- 这项研究为了解代谢物如何影响线粒体动力学和功能提供了一个框架.
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