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Updated: May 21, 2025

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通过ErbB4/PI3K-AKT通路,10-甲基-氨酸加速了伤口愈合

Yue Zhang¹, Bang-Yin Tan², Hui-Zhen Peng³

¹Yunnan Characteristic Plant Extraction Laboratory Co. Ltd, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.

Journal of ethnopharmacology

|March 21, 2025

概括

来自母草的10-甲基氨酸 (MN) 通过促进皮肤细胞的增殖和迁移,显著提高了大鼠的伤口愈合. 这种化合物有效地通过ErbB4/PI3K-AKT通路加速组织修复,优于基本纤维细胞生长因子.

科学领域:

植物化学植物化学
药理学药理学是指药理学的学科.
皮肤病学皮肤病学

背景情况:

母草 (Leonurus japonicus Houtt.) 是一个植物. 在传统中医药中具有历史,用于治疗创伤和伤口感染.
关键化合物驱动其伤口愈合特性需要识别和机械解释.

研究的目的:

为了研究10-甲基-列昂氨酸 (MN) 的伤口愈合效果.
阐明MN在伤口修复中的作用的基础分子机制.

主要方法:

使用UHPLC/Q-TOF-MS.从L. japonicus中进行植物化学分离.
在人体皮肤纤维细胞 (HSF) 增殖和迁移上隔离化合物的体外查.
在使用组织学和免疫组织化学分析的老鼠模型中进行体内伤口愈合的评估.
网络药理学和分子对接,以预测和验证分子途径.

主要成果:

10-甲基-氨酸 (MN) 显示出显著的生物活性,促进了HSF的扩散和迁移.
在老鼠中,MN治疗导致高伤口愈合率 (93.9-94.5%),超过基本纤维细胞生长因子 (bFGF).
MN增强了上皮质厚度,原沉积和α-光滑肌肉的活性表达,在S阶段增加了HSF.

结论:

MN表现出强大的伤口愈合效果,优于bFGF.
该机制涉及对ErbB4/PI3K-AKT通路的调节,由基因表达变化证明.

关键词:

10 - - 甲基 - - 列昂氨氨酸.通过ErbB4/PI3K-AKT通路进行.人体皮肤纤维细胞.狮子 (Leonurus japonicus houtt) 是一个日本.伤口愈合伤口愈合

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