腹中前额叶皮层和杏仁体之间的theta振荡支持威胁和安全的动态表示
Pingping Lu1, Dong Chen1, Wenran Xia1
1State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
NeuroImage
|March 21, 2025
概括
人类桃体-vmPFC电路通过theta振荡动态表示威胁和安全. 腹中前额叶皮层的太输入到杏仁体对于在恐惧学习和灭绝过程中处理安全信息至关重要.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 杏仁体和中腹前额皮层 (vmPFC) 是编码威胁和安全记忆的关键.
- 在恐惧处理过程中,theta振荡可能支持vmPFC-杏仁体相互作用.
- 人类vmPFC-杏仁体通路中动态神经表示的精确机制尚不清楚.
研究的目的:
- 研究人类vmPFC-杏仁体通路如何动态支持神经对反映威胁和安全的刺激的表现.
- 在恐惧调节和灭绝过程中,为该电路中的振荡调制提供直接的电生理学证据.
主要方法:
- 药物耐药性患者的内EEG记录 (n=8) 使用深度电极.
- 一个具有固定结构的恐惧调节和灭绝任务,其中刺激暗示可能是安全的或威胁的.
- 分析vmPFC与杏仁体之间的theta振荡和定向连接.
主要成果:
- 杏仁体中的theta活动增加伴随着在恐惧获取和早期灭绝过程中具有潜在威胁信息的刺激.
- 从vmPFC到杏仁体的增强的甲基导连接与学习安全信息有关.
- 人类杏仁体-vmPFC电路中威胁和安全表示的动态振荡调制的直接电生理学证据.
结论:
- 人类桃体-vmPFC电路动态调节神经对威胁和安全的表示.
- 杏仁体对安全信息的处理依赖于vmPFC在恐惧获取和灭绝过程中的甲基频输入.
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