肠道微生物群通过肠道代谢基因轴促进胆结石的形成
Wei Wang1, Kai Zhang2, Kun Zhang3
1Department of Interventional, The Second Hospital of Shandong University, Shandong, 250033, China.
Microbial pathogenesis
|March 21, 2025
概括
肠道微生物组的转变和代谢变化与胆固醇胆结石 (CGS) 有关. 诸如益生菌和ursodeoxycholic acid (UDCA) 等干预措施在减肥手术后预防CGS方面表现有前途.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 胆结石病是一个重要的健康问题,受宿主新陈代谢和肠道微生物群的影响.
- 肠道功能失调和昼夜节律扰乱与胆结石病变有关.
- 这项研究研究了胆固醇胆结石 (CGS) 患者的肠道微生物组和代谢概况.
研究的目的:
- 在CGS患者中全面分析肠道微生物群和代谢物.
- 为了确定与CGS相关的代谢变化.
- 评估益生菌和ursodeoxycholic酸 (UDCA) 在预防CGS的疗效.
主要方法:
- 多种omics方法包括16SrRNA测序,metaproteomics和代谢学.
- 分析CGS患者和健康对照的便和血清样本.
- 关于CGS预防的回顾性队列研究 腹腔外科手术后.
主要成果:
- CGS患者表现出肠道微生物群多样性的改变,有害细菌增加,有益细菌减少.
- 在氨基酸,葡萄糖,脂质和胆酸中观察到显著的代谢异常.
- Ursodeoxycholic 酸 (UDCA) 和益生菌在降低 CGS 风险后腹腔外科手术中表现出有效性,特别是在组合中.
结论:
- 多omics分析通过肠道代谢基因轴澄清了CGS病理.
- 这些发现为新的CGS预防和治疗策略铺平了道路.
- 准肠道微生物群和代谢干预措施对胆结石病具有治疗潜力.
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