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一种用于心血管植入物的抗凝固的氏丁硫酸盐/酸盐复合涂层

Bin Chu¹, Yibin Huang², Yifan Chen²

¹School of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, PR China; Key Laboratory of Biomedical Materials and Implant Devices, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, PR China.

International journal of biological macromolecules

|March 21, 2025

概括

一种新型的抗凝剂涂层使用氏丁硫酸盐和硫化为心血管植入物提供了耐用,氨酸替代方案. 这种先进的涂层通过抑制血液凝固途径来改善血相容性.

科学领域:

生物材料科学生物材料科学
心血管工程心血管工程
表面化学表面化学

背景情况:

为心血管植入物开发耐用的抗凝涂层至关重要,但具有挑战性.
标准抗凝剂 - - 氨酸 (heparin) 由于表面的快速化而受到影响.
需要有效的,持久的抗凝剂替代品.

研究的目的:

为了设计一种新的氨酸替代性抗凝剂涂层系统.
为了研究双重功能氏丁硫酸盐衍生物 (CSMAO) 和硫化奇托 (SCS) 的疗效.
评估涂层的生物相容性和心血管植入物的抗凝固特性.

主要方法:

在多多巴胺功能化的316L不钢上进行序列层层组装 (LbL).
合成和表征甲基化/化基改性氏丁硫酸盐 (CSMAO) 和硫化酸盐 (SCS).
使用FTIR,NMR和XPS进行材料表征;评估抗凝剂活性和生物相容性.

主要成果:

实现了CSMAO和SCS的特定接种和替代度 (例如,SCS的46.96%硫化).
复合材料涂层显示出出色的生物相容性.
凝血概况显示,与肝素对照对外通路调节和高级内在通路抑制相比,凝血概况相似 (P < 0.01).

结论:

一种合理设计的CSMAO/SCS复合涂层为心血管植入物提供了一个有前途的肝素替代品.
由于其双重抗凝剂机制,该涂层表现出增强的血液兼容性.
该系统具有翻译潜力,可以提高心血管器械的安全性和有效性.

关键词:

抗凝固涂层是一种抗凝固涂层.血液的兼容性血液的兼容性基托桑是一种酸盐.洪德罗二硫酸盐洪德罗二硫酸盐是一种

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