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Updated: Jun 12, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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关氨酸核酸交换因子Ric-8A调节了构成性活性Gαq对抑制剂YM-254890的敏感性

Morgan B Dwyer1, Jiansong Luo1, Tyson D Todd2

  • 1Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

The Journal of biological chemistry
|March 21, 2025
PubMed
概括

G蛋白伴侣Ric-8A影响了瘤性Gαq突变体对YM-254890 (YM) 的敏感性. 瑞克-8A促进了Gαq的激活,可能会阻碍YM的激活.

关键词:
环保环境基金 (GEF) 提供这是一个GTPase.细胞信号传递是细胞的信号传递.异构三基的G蛋白质.在基因上,我们发现了基因上的差异.血膜是一种等离子体膜.

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