患有炎症性肠道疾病的患者心律不整:加拿大马尼托巴省的一项回顾性基于人口的队列研究
Mariam Narous1, Zoann Nugent1, Inna Rabinovich-Nikitin1
1University of Manitoba Faculty of Health Sciences, Winnipeg, Manitoba, Canada.
患有炎症性肠病 (IBD) 的人面临心律不整的风险更高,甚至在心脏病诊断之前. 常见的IBD药物并没有增加这种心律失常风险.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 与各种肠外表现有关.
- IBD患者的心脏并发症需要进一步调查,特别是心律失常风险.
研究的目的:
- 调查炎症性肠病 (IBD) 与患心律不整的风险之间的关联.
- 评估IBD药物对心律失常发作的影响.
主要方法:
- 一个回顾性,基于人口的队列研究利用了曼尼托巴大学IBD流行病学数据库 (1984-2018).
- 10,992例IBD病例与102,875个匹配的对照进行了比较.
- 分析了心律失常风险,并使用查尔森共同发病率指数对并发病情况进行调整.
主要成果:
- 与对照组相比,患有IBD的患者患心律失常的可能性增加了1.51倍 (HR 1.51;95% CI,1.30至1.76).
- 在调整并发性疾病后,IBD和心律失常之间的关联仍然显著.
- 没有观察到使用5-aminosalicylates, thiopurines,或瘤坏死因子-α抑制剂时心律失常的风险增加.
结论:
- 患有IBD的人患心律不整的风险较高,独立于心脏病的诊断.
- 标准IBD药物与心律失常的风险增加无关.
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