急性髓性白血病的化疗趋势:2004年至2020年
Aditya Ravindra1, Bradley Loeffler2, Luna Acharya1
1Division of Hematology, Oncology, Blood & Bone Marrow Transplantation, University of Iowa Health Care, Iowa City, IA.
Clinical lymphoma, myeloma & leukemia
|March 21, 2025
概括
对急性髓性白血病 (AML) 的化疗使用增加,但差异仍然存在. 黑人患者和年轻人获得更好的治疗机会,但低收入和女性患者仍然面临着基本的AML治疗障碍.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 化疗对于急性髓性白血病 (AML) 治疗至关重要,提高了生存率和生活质量.
- 以前的研究表明,人口和社会经济差异显著限制了美国符合条件的AML患者的化疗接入.
研究的目的:
- 分析急性髓性白血病 (AML) 患者的化疗利用趋势.
- 确定影响化疗接收的人口和社会经济因素.
- 评估COVID-19大流行对AML治疗模式的影响.
主要方法:
- 利用国家癌症数据库 (NCDB) 对82,755名AML患者 (2004-2020) 的回顾性分析.
- 研究了两个不同时期 (2004-2010年和2011-2019年) 的化疗利用趋势,并对2020年进行了单独的分析.
- 统计分析侧重于包括年龄,种族,AML亚型,收入,并发症和性别在内的因素.
主要成果:
- 整体化疗使用率从72.9% (2004年) 增加到81.3% (2019年),在2020年略有下降至80.6%.
- 化疗接收因人口统计学因素而异:年轻患者 (18-40岁) 和黑人患者 (2010年后) 显示使用率有所改善.
- 观察到持续的差异,低收入,女性和与治疗相关的AML患者减少了化疗接入.
结论:
- 虽然在AML中使用化疗有所改善,但仍然存在显著的人口和社会经济差异.
- 有针对性的干预措施是必要的,以确保所有AML患者平等获得化疗.
- 需要进一步的研究来解决癌症治疗的持续不平等问题.
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