LuQi配方通过调节巨细胞和调节性T细胞来改善压力过载引起的心力衰竭
Xinting Wang1, Qian Liu1, Peipei Cheng1
1Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
概括
传统中国医学LuQi配方 (LQF) 通过调节心脏巨细胞和调节性T细胞 (Tregs) 来治疗心力衰竭 (HF). LQF抑制炎症性巨细胞并促进Treg招募,增强心脏免疫微环境用于HF治疗.
科学领域:
- 免疫学和心血管研究.
- 传统中国医学 药理学 药理学
背景情况:
- 失败的心肌具有炎症性巨细胞分泌CCL17,它针对免疫抑制Tregs的CCR4,抑制ARRB2-介导的心脏化学反应.
- 传统中国医学 (TCM) 的LuQi配方 (LQF) 在治疗心力衰竭 (HF) 中证明了安全性和有效性.
研究的目的:
- 阐明LQF在心力衰竭 (HF) 中的心脏保护机制.
- 在高频率的背景下,研究LQF对心脏巨细胞和调节性T细胞 (Tregs) 的调节.
主要方法:
- 使用横向大动脉收缩 (TAC) 建立了一个心力衰竭 (HF) 鼠标模型.
- 使用蛋白质组学,组织学和分子生物学技术来分析LQF的作用机制.
- 使用骨髓衍生巨细胞 (BMDMs) 和差异化Tregs的体外研究.
主要成果:
- LQF抑制了心脏炎症性巨细胞透和NF-κB (p50,p65) /CCL17轴,促进了HF模型中的Treg招募.
- 通过CD73/Foxp3轴,依赖于LQF度的增强Treg免疫抑制功能,并激活CCR4-ARRB2复合体.
- 分子对接揭示了LQF活性成分与巨细胞中的NF-κB (p50,p65) /CCL17和Tregs中的Foxp3结合.
结论:
- LQF增强了心脏免疫微环境,通过调节先天性和适应性免疫力来预防和治疗心脏免疫.
- LQF的机制包括抑制炎症性巨细胞,抑制NF-κB (p50,p65) /CCL17轴,并促进Treg招募.
- LQF的活性成分是新型抗HF药物开发的潜在候选者.
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