心率变化作为SARS-CoV-2相关脑病变的儿童早期预测因素
Yu-Shin Lee1, Hung-Tao Chung1, Shao-Hsuan Hsia2
1Department of Pediatric Cardiology, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
在患有SARS-CoV-2感染的儿童中,心率变异性降低,这些儿童患有脑病或严重疾病. 较低的心率变化可能表明患有COVID-19的严重神经并发症的风险更高.
科学领域:
- 儿科神经学 儿科神经学
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- 感染SARS-CoV-2可以导致严重的神经并发症,如儿童脑病变.
- 早期识别面临严重后果风险的儿童至关重要.
研究的目的:
- 在小儿SARS-CoV-2患者中评估心率变化 (HRV).
- 确定HRV作为发展SARS-CoV-2相关脑病变的潜在预测因子.
主要方法:
- 有证实SARS-CoV-2感染的72名儿童的潜在招生.
- 分类为脑病和非脑病组 (轻度,中度,严重/危急).
- 从1分钟心电图记录中分析心率变化指数.
主要成果:
- 15名儿童 (20.8%) 发生脑病变.
- 在脑病和严重/危急疾病组中观察到较低的HRV指数 (SDNNc,RMSSDc,SD1/SD2比).
- 这些发现与轻度和中度非脑病组进行了比较.
结论:
- 显著减少心率变化与严重的COVID-19和儿童脑病变有关.
- 人体热量值得进一步研究,因为它是预测疾病进展到脑病变的潜在生物标志物.
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