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在患有心房的患者中,多基因风险和心血管事件风险与低至中等风险的中风风险

Juntae Kim^1,2, Dongmin Kim², Daehoon Kim¹

¹Division of Cardiology, Department of Internal Medicine Yonsei University College of Medicine Seoul Republic of Korea.

Journal of the American Heart Association

|March 21, 2025

概括

心房 (AF) 的遗传风险预测了中风和全身血栓塞在中风风险较低的患者中. 这一发现有助于对心血管事件的AF患者进行分层.

科学领域:

心脏病学心脏病学
遗传学是一个遗传学.
生物信息学是一种生物信息学.

背景情况:

多基因风险评分 (PRS) 对预测心血管事件在心房患者的临床实用性仍在研究中.
目前的AF风险分层模型可能无法完全捕捉到对心血管事件的遗传倾向.

研究的目的:

评估AF特异性多基因风险评分在口服抗凝剂原始AF患者中心血管事件风险分层的有用性.
确定遗传风险是否影响AF患者发生缺血性中风,全身血栓塞,心肌梗塞或心力衰竭住院治疗的发生.

主要方法:

分析了来自英国生物库的9597名口服抗凝血原始AF患者的队列,其CHA2DS2-VA得分为0或1.
根据患者的多基因风险评分,患者被分为三级.
用治疗权重的逆概率来评估遗传风险和发生心血管事件之间的关联,平均随访时间为4.6年.

主要成果:

与低遗传风险相比,高遗传风险与缺血性中风或全身栓塞风险比率的增加显著相关 (HR1.38,P=0.011).
在高遗传风险和心肌梗塞 (HR 1.15,P=0.422) 或心力衰竭住院治疗 (HR 1.02,P=0.895) 之间没有发现显著的关联.

结论:

在心房患者中,中风风险低至中等,遗传倾向 (多原风险评分) 与中风或全身栓塞风险增加有关.
多基因风险评分可能有价值,用于完善AF相关血栓栓塞事件的风险分层.

关键词:

心房动是心房动的一种.多基因风险评分多基因风险评分.中风风险中风风险中风风险

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